Thesis Defense: Theodore Roman

When:
April 24, 2017 @ 9:00 am
2017-04-24T09:00:00-04:00
2017-04-24T09:15:00-04:00
Where:
Gates-Hillman Center 7101
CMU

Ted Roman

Title:

Understanding Tumor Composition and Evolution Through Geometric Models

Abstract:

Despite rapid progress in the understanding and treatment of disease over the course of the past 100 years,
diagnosis and treatment of cancer has 
become a focal point for basic science research. As a result,
advances 
have been made in quantifying the myriad changes in tumor genomes, transcriptomes, epigenomes,
and metagenomes as compared to healthy tissue.  
Specific to the work of this thesis, technical advances have
led to more 
robust quantification of RNA expression states via RNA-seq, and DNA copy number quantification
via DNA-seq. These approaches allow for the 
measurement of the state of tens of thousands of genes in a
sample.  
Moreover, the enhanced quantification has led to understanding the existence of heterogeneity
among tumors.

Advisor: Russell Schwartz

Committee: Adrian Lee, Robin Lee, Jessica Zhang, Jian Ma

Ted Roman Thesis Defense 2017