Curriculum: Computational Structural Biology Specialization Area

Computational Structural Biology aims at establishing biomolecular sequence-structure-function relations using fundamental principles of physical sciences in theoretical models and simulations of structure and dynamics. After the advances in complete genomes sequencing, it became evident that structural information is needed for understanding the origin and mechanisms of biological interactions, and designing/controlling function. Computational Structural Biology emerged as a tool for efficient identification of structure and dynamics in many applications. Major research topics include protein folding, protein dynamics with emphasis on large complexes and assemblies, protein-protein, protein-ligand and protein-DNA interactions and their functional implications. Drug design and protein engineering represent applications of note.

Required Life Sciences Elective (3 credits/9 units)

Pitt MSMBPH-2001

Molecular Biophysics I

Pitt BIOSC 2810

Macromolecular Structure and Function

Specialization Electives (3 credits/9 units)


CMU 15-879A

Algorithms for Computational Structural Biology

Pitt MSCBIO 2035

Computational Structural Biology II

CMU 15-873A

Advanced Algorithms for Computational Structural Biology

CMU 33-765

Statistical Mechanics

Pitt CHE 2754

Principles of Polymer Engineering

Pitt CHEM 2430

Quantum Mechanics and Kinetics

Pitt CHEM 2440

Thermodynamics & Statistical Mechanics

Pitt CHEM 3430

Introduction to Modern Computational Chemistry

Pitt CHEM 3450

Molecular Modeling and Graphics

Pitt MSCBIO 2055

Quantitative Elements of Cell Form and Movement

Pitt MSMPHL 2310

Principles of Pharmacology

Pitt MSMPHL 2370

Drug Discovery

Pitt MSMPHL 3360

Molecular Pharmacology

Pitt PHYS 2274

Computational Physics

Pitt PHYS 2541

Statistical Physics

CMU 09-560

Molecular Modeling and Computational Chemistry