“Insights into RNA processing from large-scale protein-RNA interactions”
University of California, San Diego
An increasing number of human diseases, such as neuromuscular disorders and cancer are attributed to defects in protein-RNA recognition. My lab studies how gene expression is regulated at the level of RNA processing, primarily by protein-RNA interactions. I will present our efforts in identifying new RNA binding proteins, peforming large-scale robust and reproducible transcriptome-wide measurements of protein-RNA interactions for hundreds of RNA binding proteins. If time permits I’ll discuss an example in neurodegeneration and also studying alternative splicing in single cell transcriptomic data.