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Title: Functional and fitness effects of human genetic variation
Abstract: Human genomes exhibit variation at multiple levels of biological organization. I will discuss my lab’s work using computational and statistical methods to better understand the “mosaic” nature of human genomes. This includes our research into the prevalence, causes, and consequences of mosaic aneuploidy, whereby different embryonic cells possess different numbers of chromosomes. I will also discuss our research on the mosaic ancestry of human genomes and the functional implications of persisting Neanderthal DNA acquired via ancient hybridization.
Biography: Rajiv McCoy is an assistant professor in the Department of Biology at Johns Hopkins University. The McCoy lab uses computational and statistical approaches to investigate the functional and fitness effects of human genetic variation, as well as the evolutionary mechanisms that shape such variation among cells, individuals, and populations. Dr. McCoy received his PhD in Biology from Stanford University in 2015, then completed postdoctoral work at the University of Washington and Princeton University.